ACTH 1-39, also known as Adrenocorticotropic Hormone (1-39), is the full biologically active sequence of naturally occurring ACTH, a 39-amino acid peptide hormone synthesised and secreted by corticotroph cells of the anterior pituitary gland. It represents the complete functional domain responsible for binding to melanocortin receptors, particularly MC2R, on the adrenal cortex.
In research settings, ACTH 1-39 is extensively studied for its role in stimulating the synthesis and secretion of glucocorticoids, mineralocorticoids, and adrenal androgens. It activates the hypothalamic-pituitary-adrenal (HPA) axis, making it a valuable tool in neuroendocrinology, stress response research, and adrenal function studies. Its binding to melanocortin receptors (MC1R–MC5R) has also made it a subject of interest in pigmentation, immune modulation, and metabolic regulation research.
Specifications:
– Molecular Formula: C₂₀₇H₃₀₈N₅₆O₅₈S
– Molecular Weight: 4,541.1 g/mol
– Purity: >98% (by HPLC)
– CAS Number: 9002-60-2
– Form: Lyophilised Powder
ACTH 1-39 should be stored at -20°C upon receipt and kept away from repeated freeze-thaw cycles to maintain stability. Reconstitute in sterile water or an appropriate buffer prior to use.
Molecular Formula
C₂₀₇H₃₀₈N₅₆O₅₈S
Molecular Weight
4541.1 g/mol
Purity
>98%
CAS Number
9002-60-2
Form
Lyophilised Powder
Research Applications
HPA axis research, adrenal steroidogenesis, neuroendocrinology, stress response modelling, melanocortin receptor pharmacology, immune modulation
For research purposes only. Not for human use.
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