Tesamorelin is a synthetic analogue of human growth hormone-releasing hormone (GHRH), comprising the full 44-amino acid sequence of endogenous GHRH with a trans-3-hexenoic acid group conjugated to the N-terminus. This modification enhances its stability and resistance to enzymatic degradation compared to native GHRH.
In research settings, Tesamorelin acts on pituitary somatotroph cells, binding to GHRH receptors and stimulating the pulsatile release of endogenous growth hormone (GH). The subsequent rise in GH and insulin-like growth factor 1 (IGF-1) has made it a subject of considerable interest across multiple research disciplines.
Tesamorelin has been extensively studied in the context of HIV-associated lipodystrophy, where it has demonstrated significant reductions in visceral adipose tissue (VAT). Beyond metabolic research, it is investigated for its potential roles in cognitive function, body composition, and age-related GH decline.
Storage: Store at -20°C. Protect from light and moisture. Once reconstituted, store at 4°C and use within 48–72 hours.
Molecular Formula
C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular Weight
5135.8 g/mol
Purity
>98%
CAS Number
218949-48-5
Form
Lyophilised Powder
Research Applications
Growth hormone secretion, Visceral adiposity and metabolic research, HIV-associated lipodystrophy, Body composition studies, Cognitive function research, IGF-1 axis investigation
For research purposes only. Not for human use.
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