FTPP Adipotide (also known as Prohibitin-Targeting Peptide 1) is a pro-apoptotic chimeric peptide developed for research into targeted adipose tissue reduction. The peptide consists of a targeting domain that binds to prohibitin, a protein overexpressed on the vasculature supplying white adipose tissue, linked to a pro-apoptotic domain (KLAKLAKKLAKLAK). Upon binding, FTPP Adipotide induces mitochondrial disruption and apoptosis specifically within the endothelial cells feeding adipose tissue, effectively starving fat deposits of their blood supply.
In preclinical research, FTPP Adipotide has demonstrated significant reductions in adipose tissue mass and body weight in animal models, with studies also exploring associated improvements in insulin sensitivity and metabolic markers. It is of particular interest in obesity research, metabolic syndrome investigation, and targeted vascular biology studies.
For optimal stability, store lyophilised product at -20°C, protected from light and moisture. Once reconstituted, use promptly or store at 4°C for short-term use.
Molecular Formula
C₁₁₂H₁₉₁N₃₅O₂₅
Molecular Weight
2393.0 g/mol
Purity
>98%
CAS Number
1360053-92-4
Form
Lyophilised Powder
Research Applications
Obesity research, Adipose tissue biology, Metabolic syndrome, Vascular biology, Apoptosis mechanisms, Insulin sensitivity studies
For research purposes only. Not for human use.
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