FTPP Adipotide (also referred to as Prohibitin-Targeting Peptide 1) is a chimeric proapoptotic peptide developed for research into targeted adipose tissue reduction. The compound consists of a targeting sequence that binds prohibitin on the surface of blood vessels supplying white adipose tissue, fused to a proapoptotic domain (KLAKLAK)₂ that disrupts mitochondrial membranes in targeted cells. This dual-domain mechanism results in selective apoptosis of adipose vasculature, leading to reductions in white fat mass in preclinical animal models.
In research settings, FTPP Adipotide has been investigated primarily in rodent and non-human primate models, where studies have observed significant reductions in body weight and fat mass alongside improvements in insulin sensitivity markers. These findings have positioned it as a subject of interest in obesity and metabolic disorder research.
Storage: Store lyophilised peptide at -20°C. Upon reconstitution, store at 4°C and use within 48–72 hours. Avoid repeated freeze-thaw cycles.
Molecular Formula
C₉₅H₁₄₄N₂₄O₂₅S
Molecular Weight
2033.4 g/mol
Purity
>98%
CAS Number
1159180-22-9
Form
Lyophilised Powder
Research Applications
Obesity research, Adipose tissue biology, Metabolic disorder research, Vascular targeting studies, Apoptosis pathway research, Insulin sensitivity modelling
For research purposes only. Not for human use.
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