Orexin B, also known as Hypocretin-2, is a 28-amino acid neuropeptide produced by neurones in the lateral hypothalamus. It is one of two orexin peptides (alongside Orexin A) derived from the prepro-orexin precursor protein and plays a critical role in the regulation of sleep-wake cycles, arousal, appetite, and energy homeostasis.
Orexin B exerts its effects primarily through the OX2 receptor (orexin receptor type 2), with lower affinity for OX1 receptors compared to Orexin A. This receptor selectivity makes Orexin B a valuable tool in research aimed at distinguishing the distinct physiological roles of each receptor subtype. Dysregulation of the orexin system has been implicated in narcolepsy, insomnia, depression, and metabolic disorders, making Orexin B a subject of considerable scientific interest.
This product is supplied as a lyophilised powder at >98% purity, with a molecular formula of C₁₄₃H₂₂₂N₄₀O₄₃S and a molecular weight of approximately 3,245.6 g/mol. CAS number: 127317-03-7. Store at -20°C, protected from light and moisture. Reconstitute in sterile water or appropriate buffer prior to use.
Molecular Formula
C₁₄₃H₂₂₂N₄₀O₄₃S
Molecular Weight
3,245.6 g/mol
Purity
>98%
CAS Number
127317-03-7
Form
Lyophilised Powder
Research Applications
Sleep-wake cycle regulation, Narcolepsy research, Appetite and energy homeostasis, Neuropsychiatric disorder studies, OX1/OX2 receptor pharmacology, Metabolic disorder research
For research purposes only. Not for human use.
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