MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome, making it unique among known peptides. It is derived from the 12S ribosomal RNA gene and has attracted significant scientific interest for its role in mitochondrial-to-nuclear signalling and metabolic regulation.
Research suggests that MOTS-c activates the AMPK (AMP-activated protein kinase) pathway, a central regulator of cellular energy balance. In preclinical studies, it has demonstrated the ability to enhance insulin sensitivity, promote glucose uptake in skeletal muscle, and reduce fat accumulation, positioning it as a subject of considerable interest in metabolic disease research.
Further investigations have explored MOTS-c’s potential roles in longevity, exercise mimetics, and stress response pathways. Studies suggest it may translocate to the nucleus under cellular stress conditions, where it modulates gene expression related to metabolic adaptation.
Molecular Formula
C₁₁₀H₁₇₄N₃₆O₃₂S
Molecular Weight
2174.9 g/mol
Purity
>98%
CAS Number
1627580-64-6
Form
Lyophilised Powder
Research Applications
Metabolic disorder research, Insulin sensitivity studies, Mitochondrial biology, Longevity and ageing research, Exercise physiology, Obesity and adipogenesis research
For research purposes only. Not for human use.
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