Epithalon (also known as Epitalon or Epithalone) is a synthetic tetrapeptide composed of four amino acids: Ala-Glu-Asp-Gly. Originally derived from research on the pineal peptide preparation Epithalamin, it was developed by the St. Petersburg Institute of Bioregulation and Gerontology under Professor Vladimir Khavinson. Epithalon is one of the most extensively studied peptide bioregulators in the field of ageing and longevity research.
The primary mechanism of interest involves Epithalon’s ability to activate telomerase, the enzyme responsible for maintaining and elongating telomeres — the protective caps on chromosomes that shorten with each cell division. By supporting telomere length, Epithalon is investigated as a potential modulator of cellular senescence and replicative lifespan.
Beyond telomere biology, research has explored Epithalon’s role in regulating melatonin secretion via the pineal gland, modulating neuroendocrine function, supporting antioxidant activity, and influencing gene expression related to ageing pathways. Studies have also examined its potential interactions with circadian rhythm regulation and immune function in aged models.
Specifications: Molecular Formula: C₁₄H₂₂N₄O₉ | Molecular Weight: 390.35 g/mol | Purity: >98% | CAS: 307297-39-8 | Form: Lyophilised Powder. Store at -20°C, protected from light and moisture.
Molecular Formula
C₁₄H₂₂N₄O₉
Molecular Weight
390.35 g/mol
Purity
>98%
CAS Number
307297-39-8
Form
Lyophilised Powder
Research Applications
Telomere biology and telomerase activation, Cellular ageing and senescence, Pineal gland and melatonin regulation, Neuroendocrine research, Antioxidant and oxidative stress studies, Longevity and lifespan research
For research purposes only. Not for human use.
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