5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue that plays a central role in regulating cellular energy metabolism and NAD+ biosynthesis pathways. By selectively inhibiting NNMT activity, 5-Amino-1MQ has demonstrated potential in preclinical research for modulating adipogenesis, reducing lipid accumulation, and supporting favourable metabolic profiles in in vitro and animal models.
In research settings, 5-Amino-1MQ is of significant interest in the study of obesity, metabolic syndrome, and type 2 diabetes, where dysregulated NNMT expression has been closely associated with disease progression. Studies have explored its capacity to shift cellular metabolism towards increased energy expenditure, enhance insulin sensitivity markers, and suppress the differentiation of pre-adipocytes into mature fat cells.
Each vial contains 5mg of 5-Amino-1MQ supplied as a lyophilised powder, formulated for research use. Molecular formula: C₁₀H₁₁N₂⁺ (as salt form, MW approximately 174.21 g/mol). Purity: >98% by HPLC. CAS Number: 2209816-96-4. Recommended storage is at -20°C, protected from light and moisture, with reconstitution in sterile solvent prior to use.
Molecular Formula
C₁₀H₁₁N₂⁺
Molecular Weight
174.21 g/mol
Purity
>98%
CAS Number
2209816-96-4
Form
Lyophilised Powder
Research Applications
Metabolic syndrome research, Obesity and adipogenesis studies, NNMT inhibition research, NAD+ pathway modulation, Insulin sensitivity models, Type 2 diabetes preclinical research
For research purposes only. Not for human use.
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