AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide), also known as acadesine, is a naturally occurring intermediate in the purine biosynthesis pathway and a well-established activator of AMP-activated protein kinase (AMPK). As an AMPK agonist, AICAR mimics the cellular effects of low energy status, triggering downstream signalling cascades that regulate glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and cellular metabolism.
In preclinical research, AICAR has been extensively investigated for its potential applications in metabolic disorders, including type 2 diabetes and obesity, where AMPK activation plays a central role in restoring insulin sensitivity and improving lipid profiles. Studies have also explored its relevance in cardiovascular research, where it has demonstrated cardioprotective properties, and in skeletal muscle physiology, where it has been shown to enhance oxidative capacity and endurance-like adaptations in animal models.
Additional research areas include its anti-inflammatory properties, potential neuroprotective effects, and involvement in cancer cell metabolism, where AMPK modulation may influence tumour cell energy homeostasis.
Specifications: Molecular Formula: C₉H₁₄N₄O₈P | Molecular Weight: 338.21 g/mol | Purity: >98% | CAS Number: 2627-69-2 | Form: Lyophilised Powder.
Store at -20°C, protected from light and moisture.
Molecular Formula
C₉H₁₄N₄O₈P
Molecular Weight
338.21 g/mol
Purity
>98%
CAS Number
2627-69-2
Form
Lyophilised Powder
Research Applications
Metabolic disorder research, AMPK signalling, Type 2 diabetes research, Cardiovascular physiology, Skeletal muscle endurance, Cancer cell metabolism
For research purposes only. Not for human use.
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