GDF-8, commonly known as Myostatin, is a member of the transforming growth factor-beta (TGF-β) superfamily and functions as a potent negative regulator of skeletal muscle mass. First characterised in the late 1990s, Myostatin is primarily secreted by skeletal muscle cells and acts in an autocrine and paracrine manner to suppress muscle cell proliferation and differentiation by inhibiting satellite cell activation and myoblast progression.
In research settings, GDF-8 is widely investigated for its role in muscle wasting conditions such as sarcopenia, cachexia, muscular dystrophy, and age-related muscle atrophy. Scientists also study Myostatin inhibition strategies — using GDF-8 as a reference compound — to identify potential therapeutic targets for metabolic disorders including obesity and type 2 diabetes, where muscle mass and insulin sensitivity are closely linked.
Peptician’s GDF-8 is supplied as a lyophilised powder at 95% purity, suitable for in vitro and preclinical in vivo research applications. Molecular formula: C₅₆₅H₉₀₁N₁₆₁O₁₈₂S₅. Molecular weight: approximately 12,951 Da. CAS Number: 154821-13-3. Reconstitute in sterile water or the appropriate buffer. Store lyophilised material at -20°C, protected from moisture and light; once reconstituted, store at 4°C and use within 48–72 hours.
Molecular Formula
C₅₆₅H₉₀₁N₁₆₁O₁₈₂S₅
Molecular Weight
12,951 Da
Purity
>95%
CAS Number
154821-13-3
Form
Lyophilised Powder
Research Applications
Skeletal muscle atrophy research, Sarcopenia and cachexia studies, Muscular dystrophy models, Metabolic disorder research, Myoblast differentiation studies, Muscle hypertrophy pathway investigation
For research purposes only. Not for human use.


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