IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) is a synthetic analogue of endogenous IGF-1, engineered with a 13-amino acid N-terminal extension and an arginine substitution at position 3. These modifications significantly reduce binding to IGF-binding proteins (IGFBPs), resulting in a substantially extended plasma half-life of approximately 20–30 hours compared to the 12–15 minutes observed with native IGF-1. This prolonged activity makes IGF-1 LR3 a valuable tool in in vitro and in vivo research settings.
In research, IGF-1 LR3 activates the IGF-1 receptor (IGF-1R), triggering downstream PI3K/Akt and MAPK/ERK signalling cascades. These pathways are central to the regulation of cell proliferation, differentiation, survival, and glucose metabolism. Researchers utilise IGF-1 LR3 extensively in muscle cell biology, cancer cell line studies, metabolic disorder modelling, and growth factor signalling investigations.
Storage: Store lyophilised product at -20°C. Upon reconstitution, store at 4°C and use within 14 days. Avoid repeated freeze-thaw cycles.
Molecular Formula
C400H625N111O115S9
Molecular Weight
9117.5 g/mol
Purity
>98%
CAS Number
946870-92-4
Form
Lyophilised Powder
Research Applications
Cell proliferation and differentiation research, Muscle cell biology, Cancer cell line studies, Metabolic disorder modelling, Growth factor receptor signalling, IGF-binding protein interaction studies
For research purposes only. Not for human use.
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