KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). Despite its small size, KPV exhibits remarkable biological activity, interacting with melanocortin receptors — particularly MC1R and MC3R — to exert potent anti-inflammatory and immunomodulatory effects without the hormonal activity associated with the full α-MSH molecule.
In preclinical research, KPV has been investigated for its ability to suppress pro-inflammatory cytokine production, including TNF-α, IL-1β, and IL-6, via NF-κB pathway inhibition. This positions KPV as a valuable research tool for studying inflammatory bowel disease (IBD), colitis, and other gastrointestinal inflammatory conditions. Studies have also explored its role in cutaneous wound healing, demonstrating accelerated tissue repair and reduced inflammatory infiltration at wound sites.
Additionally, KPV has shown antimicrobial properties in early-stage research, with potential relevance to infection and immunity studies.
Storage: Store at -20°C. Protect from moisture and repeated freeze-thaw cycles. Stable for up to 24 months when stored correctly.
Molecular Formula
C₁₅H₂₉N₅O₄
Molecular Weight
343.43 g/mol
Purity
>98%
CAS Number
69679-18-1
Form
Lyophilised Powder
Research Applications
Anti-inflammatory research, Inflammatory bowel disease (IBD) models, Wound healing and tissue repair, Immunomodulation, Antimicrobial activity studies, Cytokine regulation
For research purposes only. Not for human use.
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