Melanotan 1 (MT-1), also known as afamelanotide, is a synthetic linear analogue of the endogenous peptide alpha-melanocyte-stimulating hormone (α-MSH). It was developed to investigate the melanocortin receptor pathway, particularly its interaction with the melanocortin 1 receptor (MC1R), which plays a central role in regulating eumelanin production and skin pigmentation.
In research settings, MT-1 has been extensively studied for its ability to stimulate melanogenesis — the biological process responsible for melanin synthesis in melanocytes. By binding to and activating MC1R, MT-1 triggers a downstream signalling cascade involving cyclic AMP (cAMP), leading to increased tyrosinase activity and enhanced eumelanin output. This mechanism has made it a subject of interest in photoprotection research, erythropoietic protoporphyria (EPP) models, and dermatological studies.
Beyond pigmentation, MT-1 has attracted research interest in areas including immune modulation, anti-inflammatory responses, and neuroprotection, given the broad distribution of melanocortin receptors throughout peripheral and central tissues.
Storage: Store at -20°C. Protect from light and moisture. Stable for up to 24 months when stored correctly.
Molecular Formula
C₇₈H₁₁₁N₂₁O₁₉
Molecular Weight
1646.9 g/mol
Purity
>98%
CAS Number
75921-69-6
Form
Lyophilised Powder
Research Applications
Melanogenesis and pigmentation research, Photoprotection and UV response studies, Erythropoietic protoporphyria (EPP) models, Melanocortin receptor pharmacology, Immune modulation research, Dermatological and skin biology research
For research purposes only. Not for human use.
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