Orexin A, also known as Hypocretin-1, is a 33-amino acid neuropeptide produced exclusively by neurons in the lateral hypothalamus. It is one of two peptides (alongside Orexin B) derived from the prepro-orexin precursor protein and acts as an endogenous ligand for the OX1 and OX2 G-protein-coupled receptors. Orexin A displays a higher binding affinity for OX1R compared to Orexin B, making it a key tool in receptor selectivity studies.
Orexin A plays a central role in the regulation of arousal, wakefulness, and sleep-wake transitions. Dysfunction of the orexinergic system is strongly implicated in narcolepsy with cataplexy, and as such, Orexin A is extensively studied in models of sleep disorders, cognitive function, and hypothalamic signalling. Research has also explored its involvement in feeding behaviour, energy homeostasis, stress response, and reward pathways.
Each vial contains 5mg of Orexin A as a lyophilised powder with a purity of >98% as determined by HPLC analysis. Molecular formula: C₁₅₂H₂₅₁N₄₇O₄₄S₃. Molecular weight: 3561.1 g/mol. CAS Number: 167869-20-7. Store lyophilised peptide at -20°C, protected from light and moisture. Upon reconstitution, store at 4°C and use within 7 days.
Molecular Formula
C₁₅₂H₂₅₁N₄₇O₄₄S₃
Molecular Weight
3561.1 g/mol
Purity
>98%
CAS Number
167869-20-7
Form
167869-20-7
Research Applications
Sleep and wakefulness regulation, Narcolepsy and sleep disorder models, Appetite and energy homeostasis, Hypothalamic neuroendocrine signalling, Reward and addiction pathways, Stress and autonomic nervous system research
For research purposes only. Not for human use.
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