PAL-GHK, also known as Palmitoyl Tripeptide-1, is a synthetically modified derivative of the naturally occurring tripeptide GHK (Glycine-Histidine-Lysine). The palmitoyl fatty acid chain is conjugated to the N-terminus of GHK to enhance lipophilicity and facilitate improved dermal penetration, making it a subject of significant interest in topical delivery and skin biology research.
The native GHK sequence is a well-characterised copper-binding peptide with broad biological activity. In research settings, GHK and its palmitoyl derivative have been investigated for their ability to stimulate fibroblast proliferation, upregulate collagen and glycosaminoglycan synthesis, and modulate matrix metalloproteinase (MMP) activity — processes central to extracellular matrix remodelling and wound repair.
PAL-GHK has been widely studied in the context of dermal ageing, photoageing, and connective tissue biology. Research suggests it may influence the TGF-β signalling pathway, promoting pro-collagen type I and type III expression. It is also investigated for angiogenesis and anti-inflammatory mechanisms at the tissue level.
Specifications: Molecular Formula C₃₀H₅₄N₄O₅, Molecular Weight 554.78 g/mol, Purity >98% by HPLC, CAS 147732-56-7. Supplied as lyophilised powder. Store at -20°C, away from light and moisture. Stable for up to 24 months when stored correctly.
Molecular Formula
C₃₀H₅₄N₄O₅
Molecular Weight
554.78 g/mol
Purity
>98%
CAS Number
147732-56-7
Form
Lyophilised Powder
Research Applications
Extracellular matrix remodelling, Collagen synthesis research, Dermal fibroblast biology, Wound healing models, Anti-ageing and photoageing research, Topical peptide delivery studies
For research purposes only. Not for human use.
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