PEG-MGF (Pegylated Mechano Growth Factor) is a modified form of MGF, itself a splice variant of Insulin-like Growth Factor-1 (IGF-1) produced in response to mechanical stress or muscle damage. The pegylation process — the covalent attachment of polyethylene glycol (PEG) chains to the MGF peptide — significantly extends its half-life in vivo compared to native MGF, making it a highly valuable tool in longitudinal research models.
Mechanistically, PEG-MGF acts by activating muscle satellite cells (myoblasts), promoting their proliferation and differentiation into mature muscle fibres. This makes it a subject of considerable interest in studies relating to skeletal muscle repair, hypertrophy, and regenerative biology. Unlike standard MGF, the pegylated variant remains active in systemic circulation for an extended period, allowing researchers to examine sustained signalling effects on muscle tissue.
Store lyophilised product at -20°C, protected from light and moisture. Once reconstituted, store at 4°C and use within 7–14 days.
Molecular Formula
C₁₂₁H₂₀₀N₄₂O₃₉
Molecular Weight
2948.2 g/mol (peptide component; total MW dependent on PEG chain length)
Purity
>98%
CAS Number
154158-59-9
Form
Lyophilised Powder
Research Applications
Skeletal muscle repair and regeneration, Satellite cell activation and myoblast proliferation, IGF-1 splice variant signalling research, Muscle hypertrophy biology, Musculoskeletal injury recovery models, Longitudinal growth factor pharmacokinetics
For research purposes only. Not for human use.
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