PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and active metabolite of Melanotan II, developed as a melanocortin receptor agonist with a particular affinity for MC3R and MC4R subtypes. Unlike peripherally acting compounds, PT-141 exerts its effects centrally via hypothalamic pathways, making it a subject of considerable interest in neuropharmacological research.
In preclinical and clinical research settings, PT-141 has been extensively studied for its role in modulating sexual arousal and desire in both male and female animal models. Its mechanism of action involves activation of melanocortin receptors within the central nervous system, triggering downstream dopaminergic signalling pathways that influence motivation and reward circuitry.
Beyond reproductive physiology, PT-141 is also being investigated in the context of cardiovascular haemodynamics, melanocortin system regulation, and potential anti-inflammatory applications, as MC3R and MC4R are expressed across a variety of tissue types.
Store at -20°C; once reconstituted, use within 28 days and keep refrigerated at 2–8°C.
Molecular Formula
C₅₀H₆₈N₁₄O₁₀
Molecular Weight
1025.2 g/mol
Purity
>98%
CAS Number
189691-06-3
Form
Lyophilised Powder
Research Applications
Melanocortin receptor pharmacology, Sexual dysfunction research, Neuropharmacology, Hypothalamic signalling, Cardiovascular haemodynamics, Anti-inflammatory pathway research
For research purposes only. Not for human use.
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