PTD-DBM is a synthetic cell-permeable peptide designed for research into the Wnt signalling pathway, specifically targeting the PDZ domain of Dishevelled (Dvl) proteins. The peptide consists of a protein transduction domain (PTD) fused to a Dvl-binding motif (DBM), enabling intracellular delivery and direct inhibition of Dvl-mediated signalling cascades.
In research settings, PTD-DBM has been studied for its ability to disrupt Wnt/β-catenin pathway activation by competitively blocking the interaction between Dvl and its upstream regulators. This mechanism makes it a valuable tool for investigating the role of canonical and non-canonical Wnt signalling in a range of biological processes, including cell proliferation, differentiation, and tumourigenesis.
Key research applications include oncology studies, stem cell biology, developmental biology, and the investigation of fibrotic and inflammatory disease models where aberrant Wnt signalling has been implicated.
Storage: Store at -20°C upon receipt. Protect from moisture and repeated freeze-thaw cycles. Reconstitute in sterile water or suitable buffer as required.
Molecular Formula
C₇₈H₁₃₂N₂₄O₂₀S
Molecular Weight
1758.1 g/mol
Purity
>98%
CAS Number
N/A
Form
Lyophilised Powder
Research Applications
Wnt/β-catenin signalling research, oncology and tumourigenesis studies, stem cell biology, developmental biology, fibrosis research, inflammatory disease modelling
For research purposes only. Not for human use.
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