Retatrutide (also referred to as LY3437943) is an advanced triple receptor agonist that simultaneously targets glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors. This triagonist mechanism distinguishes retatrutide from dual or single receptor agonists, offering researchers a powerful tool to explore the integrated regulation of energy homeostasis, glucose metabolism, and lipid processing.
In preclinical and early clinical research, retatrutide has been associated with significant reductions in body weight and improvements in cardiometabolic markers. Its glucagon receptor activity is of particular interest for investigating hepatic glucose output and fatty acid oxidation, while the GLP-1 and GIP components contribute to insulin secretion modulation and appetite regulation research.
Peptician supplies Retatrutide as a high-purity lyophilised powder with a purity of >98% as verified by HPLC. Molecular formula: C₂₂₄H₃₅₆N₆₄O₇₂. Molecular weight: approximately 4963.5 g/mol. CAS Number: 2382744-40-1.
Storage: Store lyophilised peptide at -20°C. Once reconstituted, store at 4°C and use within 30 days. Protect from repeated freeze-thaw cycles and direct light.
Molecular Formula
C₂₂₄H₃₅₆N₆₄O₇₂
Molecular Weight
4963.5 g/mol
Purity
>98%
CAS Number
2382744-40-1
Form
Lyophilised Powder
Research Applications
Obesity and body weight regulation, Metabolic syndrome research, Glucose homeostasis, Cardiometabolic disease, Hepatic lipid metabolism, GLP-1/GIP/Glucagon receptor pharmacology
For research purposes only. Not for human use.
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