Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide found throughout the central and peripheral nervous systems, as well as in immune and endocrine tissues. It exerts its effects primarily through binding to VPAC1 and VPAC2 receptors, activating adenylyl cyclase and elevating intracellular cAMP levels, which mediates its broad range of biological actions.
In preclinical research, VIP has been extensively studied for its potent anti-inflammatory and immunomodulatory properties. It is known to suppress pro-inflammatory cytokines such as TNF-α, IL-6, and IL-12 whilst promoting regulatory T-cell activity, making it a subject of significant interest in autoimmune and inflammatory disease research. VIP also demonstrates vasodilatory effects across multiple vascular beds, bronchodilatory activity in pulmonary models, and neuroprotective properties in neurological studies.
Additionally, VIP has been investigated in the context of circadian rhythm regulation, gut motility, and neuroendocrine signalling, reflecting its diverse physiological roles.
Store at -20°C, protected from light and moisture. Reconstitute in sterile water or suitable buffer prior to use.
Molecular Formula
C₁₄₇H₂₄₅N₄₃O₄₃S
Molecular Weight
3325.7 g/mol
Purity
>98%
CAS Number
37221-79-7
Form
Lyophilised Powder
Research Applications
Anti-inflammatory and immunomodulatory research, Autoimmune disease models, Vasodilation and cardiovascular physiology, Neuroprotection and neuroscience, Pulmonary and bronchodilatory studies, Circadian rhythm and neuroendocrine signalling
For research purposes only. Not for human use. This product is intended solely for in vitro and preclinical research applications by qualified professionals.
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