Gonadorelin Acetate is a synthetic decapeptide identical in sequence to endogenous gonadotropin-releasing hormone (GnRH), the hypothalamic neuropeptide responsible for stimulating the anterior pituitary gland to release luteinising hormone (LH) and follicle-stimulating hormone (FSH). By binding to GnRH receptors on pituitary gonadotroph cells, gonadorelin initiates downstream signalling cascades that regulate gonadal steroidogenesis and gametogenesis, making it a critical tool in hypothalamic-pituitary-gonadal (HPG) axis research.
In research settings, Gonadorelin Acetate is widely utilised to investigate pulsatile GnRH signalling, receptor binding kinetics, and the neuroendocrine regulation of reproductive function. It serves as a reference compound in studies exploring hypogonadism models, fertility regulation, and the development of GnRH analogues and antagonists. Its well-characterised pharmacology also makes it valuable in comparative endocrinology and in vitro receptor assay development.
Specifications: Molecular Formula: C₅₅H₇₅N₁₇O₁₃·C₂H₄O₂ | Molecular Weight: 1182.3 g/mol (free base: 1,182.3 g/mol) | Purity: >98% by HPLC | CAS Number: 71447-49-9 | Form: Lyophilised Powder | Storage: Store at -20°C; protect from moisture and light. Stable for up to 24 months when stored correctly.
Molecular Formula
C₅₅H₇₅N₁₇O₁₃·C₂H₄O₂
Molecular Weight
1182.3 g/mol
Purity
>98%
CAS Number
71447-49-9
Form
Lyophilised Powder
Research Applications
Hypothalamic-pituitary-gonadal axis research, Reproductive endocrinology, LH and FSH secretion studies, GnRH receptor binding assays, Hypogonadism models, Fertility regulation research
For research purposes only. Not for human use.
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