IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) is a synthetic, long-acting analogue of endogenous IGF-1, engineered with an arginine substitution at position 3 and a 13-amino acid N-terminal extension. These structural modifications significantly reduce its binding affinity to IGF-binding proteins (IGFBPs), resulting in a considerably extended half-life of approximately 20–30 hours compared to native IGF-1’s half-life of minutes. This prolonged bioavailability makes IGF-1 LR3 a highly valued tool in cellular and molecular research.
In research settings, IGF-1 LR3 signals primarily through the IGF-1 receptor (IGF-1R), activating downstream pathways including PI3K/Akt and MAPK/ERK, which are associated with cell proliferation, differentiation, survival, and hypertrophy. It has been extensively studied in the context of skeletal muscle cell biology, metabolic signalling, and growth factor research.
Each vial contains 0.1mg of lyophilised IGF-1 LR3 with a purity of >98% as verified by HPLC analysis. Molecular formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉. Molecular weight: approximately 9,117.5 g/mol. CAS number: 946870-92-4. Store lyophilised product at −20°C, protected from light and moisture. Once reconstituted, store at 4°C and use within 14 days.
Molecular Formula
C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular Weight
9117.5 g/mol
Purity
>98%
CAS Number
946870-92-4
Form
Lyophilised Powder
Research Applications
Skeletal muscle cell biology, Growth factor signalling, Cell proliferation and differentiation, Metabolic regulation research, IGF-1 receptor pathway studies, In vitro hypertrophy models
For research purposes only. Not for human use.
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