MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a 16-amino acid mitochondrial-derived peptide encoded within the 12S ribosomal RNA gene of the mitochondrial genome. Unlike conventional nuclear-encoded peptides, MOTS-c represents a unique class of mitochondrial peptides that translocate to the nucleus in response to metabolic stress, where it regulates adaptive gene expression.
Mechanism of Action: MOTS-c primarily activates the AMPK (AMP-activated protein kinase) pathway, a central regulator of cellular energy homeostasis. It inhibits the folate cycle and de novo purine synthesis, leading to AICAR accumulation and downstream AMPK activation. This results in enhanced glucose uptake, improved insulin sensitivity, and increased fatty acid oxidation at the cellular level.
Research Applications: MOTS-c has attracted considerable scientific interest in the fields of metabolic disease, obesity, type 2 diabetes, ageing biology, and exercise physiology. Studies have examined its role in skeletal muscle glucose utilisation, mitochondrial biogenesis, and longevity-associated pathways. It has also been investigated in the context of age-related metabolic decline and physical performance in preclinical models.
Store at -20°C, protected from light and moisture
Molecular Formula
C₁₁₇H₂₀₂N₄₀O₃₅S
Molecular Weight
2174.4 g/mol
Purity
>98%
CAS Number
1627580-64-6
Form
Lyophilised Powder
Research Applications
Metabolic Disease Research, Insulin Sensitivity & Type 2 Diabetes Studies, Exercise Physiology & Skeletal Muscle Research, Ageing & Longevity Biology, Mitochondrial Function Research, Obesity & Energy Homeostasis Studies
For research purposes only. Not for human use.
Reviews
There are no reviews yet.