Selank (TKPRPGP) is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is an analogue of the endogenous immunomodulatory tetrapeptide tuftsin, extended with the sequence Pro-Gly-Pro to enhance metabolic stability and central nervous system activity.
In preclinical research, Selank has been investigated for its anxiolytic effects, which appear to occur without the sedative or dependency-forming properties associated with classical benzodiazepines. Its proposed mechanism of action involves modulation of GABAergic neurotransmission, upregulation of brain-derived neurotrophic factor (BDNF), and stabilisation of enkephalins — endogenous opioid peptides involved in mood regulation.
Selank has also attracted interest for its potential nootropic properties, with studies suggesting it may enhance memory consolidation, learning capacity, and attention. Additional research has examined its immunomodulatory effects, particularly its influence on interleukin expression and T-cell activity.
Specifications: Molecular Formula: C₃₃H₅₇N₁₁O₉ | Molecular Weight: 751.88 g/mol | Purity: >98% (HPLC) | CAS Number: 129954-34-3 | Form: Lyophilised Powder.
Storage: Store at -20°C. Protect from light and moisture. Stable for 24 months when stored correctly.
Molecular Formula
C₃₃H₅₇N₁₁O₉
Molecular Weight
751.88 g/mol
Purity
>98%
CAS Number
129954-34-3
Form
Lyophilised Powder
Research Applications
Anxiolytic research, Nootropic and cognitive function studies, Immunomodulation research, Neurotrophic factor expression, GABAergic neurotransmission, Mood and stress response modelling
For research purposes only. Not for human use.
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