Thymosin Alpha 1 (Tα1) is a naturally occurring 28-amino acid peptide originally isolated from thymosin fraction 5 of the thymus gland. First characterised by Allan Goldstein in the 1970s, it plays a central role in the maturation and differentiation of T-lymphocytes, making it one of the most extensively studied immunomodulatory peptides in contemporary biomedical research.
In research settings, Thymosin Alpha 1 is understood to exert its effects primarily by activating Toll-like receptor 9 (TLR9) signalling pathways, promoting dendritic cell maturation, and enhancing both innate and adaptive immune responses. It has been investigated across a broad range of in vitro and in vivo models relating to viral infections, immune deficiency states, and inflammatory conditions.
Key research applications include immunology and T-cell biology, antiviral and antimicrobial defence mechanisms, oncology immunotherapy models, and sepsis or systemic inflammatory response studies. It has also been explored in models of chronic hepatitis B and C infection, as well as HIV-associated immune dysfunction.
Store at −20°C, protected from light and moisture. Reconstitute with sterile bacteriostatic water prior to use in experimental protocols.
Molecular Formula
C₁₂₉H₂₁₅N₃₃O₅₅S
Molecular Weight
3108.3 g/mol
Purity
>98%
CAS Number
62304-98-7
Form
Lyophilised Powder
Research Applications
Immunomodulation, T-cell activation and differentiation, Antiviral defence mechanisms, Oncology immunotherapy models, Sepsis and inflammatory response research, Chronic viral infection models
For research purposes only. Not for human use.
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