Semaglutide 20mg – 10 vials

Semaglutide is a synthetic analogue of glucagon-like peptide-1 (GLP-1), a naturally occurring incretin hormone secreted by intestinal L-cells in response to nutrient ingestion. Structurally, semaglutide shares approximately 94% sequence homology with native human GLP-1, with key modifications — including a C18 fatty diacid chain attached via a linker to lysine at position 26 — that confer exceptional resistance to dipeptidyl peptidase-4 (DPP-4) degradation and albumin binding, resulting in a prolonged plasma half-life of approximately 7 days.

As a GLP-1 receptor agonist, semaglutide activates GLP-1R on pancreatic beta cells to stimulate glucose-dependent insulin secretion, whilst simultaneously suppressing glucagon release. Central GLP-1R activation in the hypothalamus and brainstem has been extensively studied in the context of appetite regulation and energy homeostasis.

Research applications include investigations into type 2 diabetes mechanisms, obesity and adiposity models, cardiovascular risk factor modulation, non-alcoholic steatohepatitis (NASH), and neurological appetite signalling pathways. Semaglutide has also attracted growing interest in neuroprotection and cognitive function research.

Specifications: Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉, Molecular Weight: 4113.6 g/mol, Purity: >98% by HPLC, CAS Number: 910463-68-2. Supplied as lyophilised powder. Store at -20°C, protected from light and moisture. Reconstitute in sterile bacteriostatic water.

For research purposes only. Not for human use.